aga model group Search Results


aga model group  (MedChemExpress)
94
MedChemExpress aga model group
Establishment of <t>AGA</t> model and treatments. (A) Schematic diagram of the establishment of the AGA model and treatments. (B) Immunofluorescence staining, section scanning, and whole-mount imaging of clarified tissues demonstrating the transdermal efficacy of TQC and tFNAs. Blue: DAPI; Red: Cy5-TQC/Cy5-tFNAs. (C) Time-course observations of hair growth of samples at 1, 4, 7, 10, 14, 15, 18, 21, 24, and 28 days (n = 5). (D) Whole-mount imaging and magnified views of treated samples shot with a Light Microscopy: Control, <t>AGA,</t> <t>Minoxidil,</t> Que, tFNAs, and TQC (n = 5). (D) (E) Longitudinal-sectional and cross-sectional HE staining of treatment groups: Control, AGA, Minoxidil, tFNAs, Que, and TQC. Scale bars: 3 mm (overview), 300 μm/500 μm (magnified regions). Black triangle: Sebaceous gland; black arrowheads: Hair shaft; yellow arrowheads: Hair bulb; green arrowheads: Hair papilla; blue arrowheads: Melanocyte (n = 5). (F) Quantitative image analysis of whole mount hair follicles density (number/view) in figure D. Data are expressed as mean ± SD (n = 5). Statistical significance was determined by one-way ANOVA with Tukey's post hoc test. (G) Quantitative image analysis of hair follicle density (number/mm) in cross-sectional HE staining (figure E). Data are expressed as mean ± SD (n = 5). Statistical significance was determined by one-way ANOVA with Tukey's post hoc test. (H) Ratio of anagen to telogen follicles in longitudinal-sectional HE staining (figure E). Data represent mean ± SD (n = 5) and are analyzed using one-way ANOVA with Tukey's test. The following symbols denote differences compared to each group: (∗) control, (#) AGA, (&) AGA + Minoxidil, (@) AGA + tFNAs, ($) AGA + Que. Significance levels are: ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001.
Aga Model Group, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/aga model group/product/MedChemExpress
Average 94 stars, based on 1 article reviews
aga model group - by Bioz Stars, 2026-02
94/100 stars
  Buy from Supplier

Image Search Results


Establishment of AGA model and treatments. (A) Schematic diagram of the establishment of the AGA model and treatments. (B) Immunofluorescence staining, section scanning, and whole-mount imaging of clarified tissues demonstrating the transdermal efficacy of TQC and tFNAs. Blue: DAPI; Red: Cy5-TQC/Cy5-tFNAs. (C) Time-course observations of hair growth of samples at 1, 4, 7, 10, 14, 15, 18, 21, 24, and 28 days (n = 5). (D) Whole-mount imaging and magnified views of treated samples shot with a Light Microscopy: Control, AGA, Minoxidil, Que, tFNAs, and TQC (n = 5). (D) (E) Longitudinal-sectional and cross-sectional HE staining of treatment groups: Control, AGA, Minoxidil, tFNAs, Que, and TQC. Scale bars: 3 mm (overview), 300 μm/500 μm (magnified regions). Black triangle: Sebaceous gland; black arrowheads: Hair shaft; yellow arrowheads: Hair bulb; green arrowheads: Hair papilla; blue arrowheads: Melanocyte (n = 5). (F) Quantitative image analysis of whole mount hair follicles density (number/view) in figure D. Data are expressed as mean ± SD (n = 5). Statistical significance was determined by one-way ANOVA with Tukey's post hoc test. (G) Quantitative image analysis of hair follicle density (number/mm) in cross-sectional HE staining (figure E). Data are expressed as mean ± SD (n = 5). Statistical significance was determined by one-way ANOVA with Tukey's post hoc test. (H) Ratio of anagen to telogen follicles in longitudinal-sectional HE staining (figure E). Data represent mean ± SD (n = 5) and are analyzed using one-way ANOVA with Tukey's test. The following symbols denote differences compared to each group: (∗) control, (#) AGA, (&) AGA + Minoxidil, (@) AGA + tFNAs, ($) AGA + Que. Significance levels are: ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001.

Journal: Bioactive Materials

Article Title: Sustainability of functional hair follicle activity: Impact of spatially anchored multifunctional tetrahedral framework nucleic acids

doi: 10.1016/j.bioactmat.2025.11.006

Figure Lengend Snippet: Establishment of AGA model and treatments. (A) Schematic diagram of the establishment of the AGA model and treatments. (B) Immunofluorescence staining, section scanning, and whole-mount imaging of clarified tissues demonstrating the transdermal efficacy of TQC and tFNAs. Blue: DAPI; Red: Cy5-TQC/Cy5-tFNAs. (C) Time-course observations of hair growth of samples at 1, 4, 7, 10, 14, 15, 18, 21, 24, and 28 days (n = 5). (D) Whole-mount imaging and magnified views of treated samples shot with a Light Microscopy: Control, AGA, Minoxidil, Que, tFNAs, and TQC (n = 5). (D) (E) Longitudinal-sectional and cross-sectional HE staining of treatment groups: Control, AGA, Minoxidil, tFNAs, Que, and TQC. Scale bars: 3 mm (overview), 300 μm/500 μm (magnified regions). Black triangle: Sebaceous gland; black arrowheads: Hair shaft; yellow arrowheads: Hair bulb; green arrowheads: Hair papilla; blue arrowheads: Melanocyte (n = 5). (F) Quantitative image analysis of whole mount hair follicles density (number/view) in figure D. Data are expressed as mean ± SD (n = 5). Statistical significance was determined by one-way ANOVA with Tukey's post hoc test. (G) Quantitative image analysis of hair follicle density (number/mm) in cross-sectional HE staining (figure E). Data are expressed as mean ± SD (n = 5). Statistical significance was determined by one-way ANOVA with Tukey's post hoc test. (H) Ratio of anagen to telogen follicles in longitudinal-sectional HE staining (figure E). Data represent mean ± SD (n = 5) and are analyzed using one-way ANOVA with Tukey's test. The following symbols denote differences compared to each group: (∗) control, (#) AGA, (&) AGA + Minoxidil, (@) AGA + tFNAs, ($) AGA + Que. Significance levels are: ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001.

Article Snippet: After 14 days’ model establishment, the mice were assigned to the following groups: AGA model group, Minoxidil ( U10858 , MCE, USA, 5 %)-treated group, Que (20 μM)-treated group, tFNAs (250 nM)-treated group, and TQC (tFNAs/Que: 250 nM/20 μM)-treated group.

Techniques: Immunofluorescence, Staining, Imaging, Light Microscopy, Control

The role of TQC in mediating Wnt/β-catenin signaling and hair follicle regeneration in AGA mice. (A) Western blot analysis of β-catenin, GSK3β, CK-1α, and APC protein expression in different treatment groups. GAPDH was used as an internal control (n = 5). (B) Quantitative analysis of protein expression levels relative to the control group. Data are expressed as mean ± SD (n = 5). Statistical significance was determined by one-way ANOVA with Tukey's post hoc test. (C) Immunohistochemical staining of GSK3β, CK-1α, and APC in skin tissue sections. Magnified images show representative areas of staining. Scale bars: 3 mm (original magnification) and 500 μm (magnified), (n = 5). (D) Immunofluorescent staining of Ki67 (green) and KRT14 (red) in skin sections. DAPI (blue) was used for nuclear staining. Merged images show the co-localization of Ki67 and KRT14. Scale bars: 2 mm (original magnification) and 200 μm (magnified). (E) Quantification of β-catenin, GSK3β, and CK-1α protein expression on immunofluorescent staining sections calculated by ImageJ (n = 5). Data are expressed as mean ± SD (n = 5). Statistical significance was determined by one-way ANOVA with Tukey's post hoc test. (F) Quantification of Ki67 and KRT14 positive area. Data are expressed as mean ± SD (n = 5). Statistical significance was determined by one-way ANOVA with Tukey's post hoc test. The following symbols denote significant differences compared to each group: (∗) control, (#) AGA, (&) AGA + Minoxidil, (@) AGA + tFNAs, ($) AGA + Que. Significance levels are: ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001.

Journal: Bioactive Materials

Article Title: Sustainability of functional hair follicle activity: Impact of spatially anchored multifunctional tetrahedral framework nucleic acids

doi: 10.1016/j.bioactmat.2025.11.006

Figure Lengend Snippet: The role of TQC in mediating Wnt/β-catenin signaling and hair follicle regeneration in AGA mice. (A) Western blot analysis of β-catenin, GSK3β, CK-1α, and APC protein expression in different treatment groups. GAPDH was used as an internal control (n = 5). (B) Quantitative analysis of protein expression levels relative to the control group. Data are expressed as mean ± SD (n = 5). Statistical significance was determined by one-way ANOVA with Tukey's post hoc test. (C) Immunohistochemical staining of GSK3β, CK-1α, and APC in skin tissue sections. Magnified images show representative areas of staining. Scale bars: 3 mm (original magnification) and 500 μm (magnified), (n = 5). (D) Immunofluorescent staining of Ki67 (green) and KRT14 (red) in skin sections. DAPI (blue) was used for nuclear staining. Merged images show the co-localization of Ki67 and KRT14. Scale bars: 2 mm (original magnification) and 200 μm (magnified). (E) Quantification of β-catenin, GSK3β, and CK-1α protein expression on immunofluorescent staining sections calculated by ImageJ (n = 5). Data are expressed as mean ± SD (n = 5). Statistical significance was determined by one-way ANOVA with Tukey's post hoc test. (F) Quantification of Ki67 and KRT14 positive area. Data are expressed as mean ± SD (n = 5). Statistical significance was determined by one-way ANOVA with Tukey's post hoc test. The following symbols denote significant differences compared to each group: (∗) control, (#) AGA, (&) AGA + Minoxidil, (@) AGA + tFNAs, ($) AGA + Que. Significance levels are: ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001.

Article Snippet: After 14 days’ model establishment, the mice were assigned to the following groups: AGA model group, Minoxidil ( U10858 , MCE, USA, 5 %)-treated group, Que (20 μM)-treated group, tFNAs (250 nM)-treated group, and TQC (tFNAs/Que: 250 nM/20 μM)-treated group.

Techniques: Western Blot, Expressing, Control, Immunohistochemical staining, Staining